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Sci Rep. 2017 Nov 28;7(1):16527. doi: 10.1038/s41598-017-16606-9.

Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants.

Author information

1
Department of Medicine, McMaster University, Hamilton, Canada. stearns@mcmaster.ca.
2
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada. stearns@mcmaster.ca.
3
Midwifery Education Program, McMaster University, Hamilton, Canada.
4
Department of Pediatrics, McMaster University, Hamilton, Canada.
5
Department of Obstetrics & Gynecology, McMaster University, Hamilton, Canada.
6
Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada.
7
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada.
8
Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Canada.
9
Department of Medicine, McMaster University, Hamilton, Canada.

Abstract

Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles  of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer duration of IAP exposure increased the magnitude of the effect on Bifidobacterium populations, suggesting a longer delay in microbial community maturation. As with prior studies, we found altered gut colonisation following C-section that included a notable lack of Bacteroidetes. This study found that exposure of infants to IAP for GBS during vaginal birth affected aspects of gut microbial ecology that, although dramatic at early time points, disappeared by 12 weeks of age in most infants.

PMID:
29184093
PMCID:
PMC5705725
DOI:
10.1038/s41598-017-16606-9
[Indexed for MEDLINE]
Free PMC Article

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