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J Toxicol Environ Health B Crit Rev. 2017;20(8):447-469. doi: 10.1080/10937404.2017.1399306.

Triclosan exposure, transformation, and human health effects.

Author information

1
a Graduate School of Biomedical Science and Engineering , University of Maine , Orono , ME , USA.
2
b Department of Molecular and Biomedical Sciences , University of Maine , Orono , ME , USA.

Abstract

Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. TCS is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems, was also summarized.

PMID:
29182464
PMCID:
PMC6126357
DOI:
10.1080/10937404.2017.1399306
[Indexed for MEDLINE]
Free PMC Article

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