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Environ Sci Pollut Res Int. 2018 Feb;25(5):4309-4319. doi: 10.1007/s11356-017-0786-4. Epub 2017 Nov 27.

Effect of gasoline fumes on reproductive function in male albino rats.

Author information

1
Department of Zoology, Faculty of Science, Olabisi Onabanjo University, Ago- Iwoye, Ogun State, Nigeria. fobillion@yahoo.com.
2
Department of Pure and Applied Zoology, College of Bioscience, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
3
Department of Plant Science, Faculty of Science, Olabisi Onabanjo University, Ago- Iwoye, Ogun State, Nigeria.
4
Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.

Abstract

The increase in the frequency of exposure to gasoline fumes and the growing incidence of infertility among humans has been a major concern and subject of discussion over the years in Nigeria. We therefore present the reproductive effect of gasoline fumes on inhalation exposure in 40 male albino rats. The rats were randomized into five experimental treatments (T) with eight rats per treatment. T1 (control) was exposed to distilled water while T2, T3, T4, and T5 were exposed to gasoline fumes in exposure chambers for 1, 3, 5, and 9 h daily respectively for 12 weeks. Serum level of testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, oxidative stress markers in the testicular tissue, epididymal sperm health assessment, and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction. Significant (p < 0.05) alterations in the levels of all the reproductive hormones and oxidative stress markers assayed were observed in rats exposed to gasoline fume. Significant reductions (p < 0.05) in sperm count and percentage motility in the exposed rats were observed. Significant (p < 0.05) increased in abnormal sperm cells characterized by damaged head, bent tail, damaged tail, and without head were also observed in the exposed rats. Histopathologically, severe degenerative testicular architectural lesions characterized by alterations in all the generations of sperm cells and reduction of interstitial cells were seen in the exposed rats. Gasoline fume is thus said to interfere with spermatogenesis and impair fertility in male gonad.

KEYWORDS:

Environmental pollution; Gasoline; Infertility; Reproductive hormone; Sperm morphology; Xenobiotics

PMID:
29181751
DOI:
10.1007/s11356-017-0786-4
[Indexed for MEDLINE]

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