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Inflamm Res. 2018 Apr;67(4):279-284. doi: 10.1007/s00011-017-1117-4. Epub 2017 Nov 27.

Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance?

Author information

1
Institute of Pathophysiology, Centre for Molecular Medicine, Medical University of Graz, Heinrichstrasse 31a, 8010, Graz, Austria. w.schnedl@dr-schnedl.at.
2
Department of Internal Medicine, Practice for General Internal Medicine, Dr. Theodor Körnerstrasse 19b, 8600, Bruck/Mur, Austria. w.schnedl@dr-schnedl.at.
3
Institute of Pathophysiology, Centre for Molecular Medicine, Medical University of Graz, Heinrichstrasse 31a, 8010, Graz, Austria.
4
Institute of Laboratory Medicine, General Hospital Steyr, Sierninger Straße 170, 4400, Steyr, Austria.
5
Das Kinderwunsch Institut Schenk GmbH, Am Sendergrund 11, 8143, Dobl, Austria.
6
Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, 8036, Graz, Austria.

Abstract

INTRODUCTION:

Food intolerance/malabsorption is caused by food ingredients, carbohydrates (mainly lactose and fructose), proteins (gluten), and biogenic amines (histamine) which cause nonspecific gastrointestinal and extra-intestinal symptoms. Here we focus on possible etiologic factors of intolerance/malabsorption especially in people with non-celiac gluten sensitivity (NCGS) or the so-called people without celiac disease avoiding gluten (PWCDAG) and histamine intolerance.

METHODS:

Recognizing the recently described symptoms of NCGS (PWCDAG) we review correlations and parallels to histamine intolerance (HIT).

RESULTS:

We show that intestinal and extra-intestinal NCGS (PWCDAG) symptoms are very similar to those which can be found in histamine intolerance.

CONCLUSIONS:

After a detailed diagnostic workup for all possible etiologic factors in every patient, a targeted dietary intervention for single or possibly combined intolerance/malabsorption might be more effective than a short-term diet low in fermentable oligo-, di- and monosaccharides and polyols (FODMAP) or the untargeted uncritical use of gluten-free diets.

KEYWORDS:

Diamine oxidase; Food intolerance; Food malabsorption; Histamine intolerance; Non-celiac gluten sensitivity

PMID:
29181545
DOI:
10.1007/s00011-017-1117-4
[Indexed for MEDLINE]

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