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PeerJ. 2017 Nov 23;5:e4083. doi: 10.7717/peerj.4083. eCollection 2017.

Associations of IGF2 and DRD2 polymorphisms with laying traits in Muscovy duck.

Ye Q1,2, Xu J1,2, Gao X1,2, Ouyang H1,2, Luo W1,2, Nie Q1,2.

Author information

1
National-Local Joint Engineering Research Center for Livestock Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
2
Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, Guangdong, China.

Abstract

Insulin-like growth factor 2 (IGF2) and dopamine receptor 2 (DRD2) play important roles in ovarian follicular development. In this study, we analyzed tissue-specific expression of the Muscovy duck IGF2 and DRD2 genes and cloned those genes transcripts. Polymorphisms in these genes were tightly linked with egg production traits and both genes were highly expressed in the ovary. Moreover, we identified five single nucleotide polymorphisms (SNPs) for IGF1 and 28 for DRD2. Mutations A-1864G and C-1704G of IGF2 were positively correlated with increased egg laying at 59 weeks (E59W) (P < 0.05). The C+7T and C+364G mutations of DRD2 were highly and significantly associated with first-egg age (FEA) and egg numbers at 300 days (E300D) (P < 0.01). Moreover, C+3301G and C+3545G of DRD2 were highly significantly associated with FEA, E59W and E300D (P < 0.01). Other mutations were positively associated with FEA or E300D or E59W (P < 0.05). These data suggest specific roles for IGF1 and DRD2 polymorphisms in egg production in Muscovy ducks.

KEYWORDS:

Association analysis; Dopamine receptor 2; Egg production traits; Insulin-like growth factor 2; Muscovy duck; Polymorphisms

Conflict of interest statement

The authors declare there are no competing interests.

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