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Arch Osteoporos. 2017 Nov 25;12(1):106. doi: 10.1007/s11657-017-0403-7.

Osteoporosis is associated with increased risk for benign paroxysmal positional vertigo: a nationwide population-based study.

Chan KC1,2,3, Tsai YT2,3,4, Yang YH5,6,7, Chen PC8,9, Chang PH10,11,12.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kwei-Shan, Taoyuan, 333, Taiwan.
2
School of Medicine, Chang Gung University, Taoyuan, Taiwan.
3
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan.
4
Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
5
Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
6
Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi, Taiwan.
7
School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
8
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
9
Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
10
Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kwei-Shan, Taoyuan, 333, Taiwan. bc1766@gmail.com.
11
School of Medicine, Chang Gung University, Taoyuan, Taiwan. bc1766@gmail.com.
12
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan. bc1766@gmail.com.

Abstract

Recent evidence has indicated that osteoporosis is a risk factor for benign paroxysmal positional vertigo (BPPV). This large population-based study demonstrated that patients with osteoporosis had a 1.82-fold higher risk of developing BPPV than those without osteoporosis through the use of the Taiwan National Health Insurance Research Database.

PURPOSE:

Benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of vertigo. Osteoporosis reflects a homeostatic imbalance in the rate of bone turnover, with the rate of bone resorption exceeding that of bone formation. Recent evidence has indicated that osteoporosis is a risk factor for BPPV. We aimed to validate the risk of BPPV in osteoporotic patients through a nationwide, population-based, cohort study.

METHODS:

Patients treated for osteoporosis were identified from entries made in the Taiwan National Health Insurance Research Database (NHIRD) between 2000 and 2013. Each osteoporosis patient was age- and sex-matched with four randomly selected subjects without osteoporosis. We compared the incidence rates of BPPV in the two cohorts (with and without osteoporosis) and identified risk factors.

RESULTS:

We identified 6649 osteoporosis patients and 26,596 match controls. According to the incidence of BPPV among the two groups, patients with osteoporosis were found to have a 1.82-fold higher risk of developing BPPV than those without osteoporosis. The incidence rate ratio (IRR) between osteoporotic patients and the control cohort was 2.0 (pā€‰<ā€‰0.001).

CONCLUSIONS:

This large population-based study demonstrated that patients with osteoporosis were associated with an increased risk for BPPV. The results of this study provide some insight into the management of BPPV.

KEYWORDS:

BPPV; Osteoporosis; Vertigo

PMID:
29177633
DOI:
10.1007/s11657-017-0403-7
[Indexed for MEDLINE]

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