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Phys Chem Chem Phys. 2018 Jan 24;20(4):2155-2161. doi: 10.1039/c7cp05981g.

Probing molecular forces in multi-component physiological membranes.

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CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India.


Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids.

[Indexed for MEDLINE]

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