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Phys Chem Chem Phys. 2018 Jan 24;20(4):2155-2161. doi: 10.1039/c7cp05981g.

Probing molecular forces in multi-component physiological membranes.

Author information

1
CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India. lipi.thukral@igib.res.in.

Abstract

Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids.

PMID:
29177331
DOI:
10.1039/c7cp05981g
[Indexed for MEDLINE]

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