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Pak J Pharm Sci. 2017 Nov;30(6):2165-2172.

Evaluation of cytotoxic and antiviral activities of aqueous leaves extracts of different plants against foot and mouth disease virus infection in farming animals.

Author information

1
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan / Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
2
Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
3
Faculty of Pharmacy, Dow University of Health Science, Karachi, Pakistan.
4
Microbiology section, Quality Operations Laboratory, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Abstract

Cytotoxic and antiviral activity of aqueous leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus (FMDV) were determined using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Eight different concentrations of each plant were evaluated. Cytotoxic and antiviral activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. From the tested plant extracts, Azadirachta indica & Moringa oleifera exhibited cytotoxicity at 200 & 100 μ/ml respectively. In case of antiviral assay, Moringa oleifera showed potent antiviral activity (p<0.05) while Azadirachta indica showed significant antiviral activity in the range of 12.5-50 μ/ml & 50-100 μ/ml respectively. In contrast no anti-FMDV activity in the present study was observed with Morus alba, although all the tested concentrations were found to be safe.

PMID:
29175786

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