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Food Chem Toxicol. 2018 Jan;111:405-416. doi: 10.1016/j.fct.2017.11.047. Epub 2017 Nov 23.

Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.

Author information

1
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
2
Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA 01003, USA.
3
Department of Biological Sciences and Environmental Sciences Program, Southern Illinois University, Edwardsville, IL 62026, USA.
4
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.
5
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: ypark@foodsci.umass.edu.

Abstract

Permethrin is a pyrethroid pesticide that was previously reported to promote fat accumulation and insulin resistance in vitro. A recent study in female mice also found that permethrin could promote high fat-induced insulin resistance. The effects of permethrin on glucose and lipid metabolisms in male mice, however, remain unknown. The purpose of this study was to investigate the effects and interactions of permethrin exposure (50, 500, and 5000 μg/kg body weight/day) and dietary fat (low fat, 4% w/w; high fat, 20% w/w) on development of obesity and insulin resistance in male C57BL/6J mice. Our results showed that permethrin treatment significantly increased body weight, fat mass, and insulin resistance with high fat diet, but not with low fat diet, without influencing energy intake. Permethrin treatment also significantly increased serum levels of insulin, glucose, leptin, triglycerides and cholesterol. Further results showed that permethrin inhibited AMP-activated protein kinase in white adipose tissue. These results suggest that permethrin interacts with dietary fat to alter lipid and glucose metabolisms in male C57BL/6J mice.

KEYWORDS:

Glucose metabolism; Insecticide; Obesity; Permethrin

PMID:
29175578
PMCID:
PMC5756676
DOI:
10.1016/j.fct.2017.11.047
[Indexed for MEDLINE]
Free PMC Article

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