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J Oral Maxillofac Surg. 2018 Feb;76(2):314.e1-314.e9. doi: 10.1016/j.joms.2017.10.023. Epub 2017 Nov 23.

Association Between Polymorphisms in the Genes of Estrogen Receptors and the Presence of Temporomandibular Disorders and Chronic Arthralgia.

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Doctoral Student of Dentistry, Fluminense Federal University, Niterói, RJ, Brazil. Electronic address:
Doctor in Dentistry, Fluminense Federal University, Niterói; Specialist in Temporomandibular Disorders and Orofacial Pain, School of Medicine, Petrópolis, RJ, Brazil.
Doctor in Oral Biology, Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA.
Doctor in Chemistry and Cell Therapy Center, Clinical Research Unit and Biology Institute, Fluminense Federal University, Niterói; National Institute of Metrology, Quality and Technology, Rio de Janeiro, RJ, Brazil.
Master of Health Sciences and Assistant Professor and Specialist in Temporomandibular Disorders and Orofacial Pain, School of Medicine, Petrópolis, RJ, Brazil; Professor of Specialization Courses in Orthodontics, Brazilian Dental Association, Petrópolis and Duque de Caxias, RJ, Brazil; Professor of Orthodontics of the Specialization Course, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic.
Doctor in Morphology and Adjunct Professor of Periodontics, Fluminense Federal University, Niterói, RJ, Brazil.



The high prevalence of painful temporomandibular disorders (TMDs) in women suggests that estrogen and its receptors play a fundamental etiologic role in the development of this joint pathology through complex action mechanisms. The aim of this study was to evaluate the possible association between polymorphisms in the ESR1 (estrogen receptor-1) and ESRRB (estrogen-related receptor-β) genes and the risk of simultaneous development of TMDs and pain in other joints in the body.


All participants were clinically evaluated for the presence of TMD (Research Diagnostic Criteria for TMD) and asked about the presence of chronic joint pain. The control group consisted of 72 patients without TMD and without pain. Participants with arthralgia were divided into 3 groups: with muscular TMD (n = 42), with articular TMD (n = 16), and without TMD and with systemic arthralgia (n = 82). Eight single-nucleotide polymorphisms in the ESR1 (rs12154178, rs1884051, rs2273206, rs7774230) and ESRRB (rs1676303, rs4903399, rs10132091, rs7151924) genes were investigated. The χ2 test and Student t and Mann-Whitney tests were used to assess the relevance of nominal and continuous variables, respectively. A P value less than .05 was considered significant.


The TT (timin/timin) genotype for the ESR1 (rs2273206) gene was strongly associated with the risk of developing muscle TMDs and temporomandibular joint pain (P = .04). For the ESRRB (rs1676303) gene, an association was observed between the CC (cytosine/cytosine) genotype and the presence of articular TMDs associated with other chronic arthralgia (P = .02). These results were confirmed by the increased risk of developing articular TMDs associated with the C allele (P = .04).


This study supports the hypothesis that changes in the ESR1 and ESRRB genes influence the presence of TMDs associated with chronic joint pain.


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