Format

Send to

Choose Destination
Addict Behav. 2018 Mar;78:173-177. doi: 10.1016/j.addbeh.2017.11.021. Epub 2017 Nov 16.

Parachuting psychoactive substances: Pharmacokinetic clues for harm reduction.

Author information

1
Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, F-33000 Bordeaux, France; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France. Electronic address: amelie.daveluy@u-bordeaux.fr.
2
Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, F-33000 Bordeaux, France.
3
Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, F-33000 Bordeaux, France; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France; Laboratoire de droit et économie pharmaceutiques, Univ. Bordeaux, F-33000 Bordeaux, France.
4
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France.
5
Laboratoire de technologies pharmaceutiques industrielles (LTPIB), Univ. Bordeaux, F-33000 Bordeaux, France.
6
Comité d'étude et d'information sur la drogue et les addictions (CEID-Addictions), F-33000 Bordeaux, France.
7
Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, F-33000 Bordeaux, France; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France.

Abstract

BACKGROUND:

Parachuting, also called bombing, is a way to ingest psychoactive substances wrapped into cigarette paper, toilet paper, etc. There is little data describing parachuting in terms of substances use, context of use and, most importantly, the motivations for using such wrappers, although some authors hypothesized that parachute could be used for pharmacokinetic reason. However, inconsistently, some authors report that parachutes are used for sustained-release whereas others report that users are looking for an immediate effect.

RESEARCH DESIGN AND METHODS:

Considering parachute as a "home-made" dosage form, we have applied the dissolution testing to characterize the dissolution performance of a substance wrapped into a parachute and to characterize whether a parachute represents an immediate-release form or not.

RESULTS:

This in-vitro study provides the first pharmacokinetic data for drugs wrapped in parachutes. It shows that parachute acts as sustained-release form when made with a cigarette paper wrapper, but as immediate release form in the presence of alcohol or if wrapped with toilet paper.

CONCLUSIONS:

An important message to harm reduction is that users must be aware that a parachute can have unexpected pharmacokinetics and have to avoid taking another parachute in the absence of an immediate-effect to avoid overdose.

KEYWORDS:

Dosage forms; Harm reduction; Parachuting; Pharmacokinetics; Substance-related disorders

PMID:
29175294
DOI:
10.1016/j.addbeh.2017.11.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center