Format

Send to

Choose Destination
Brain Behav Immun. 2018 Mar;69:235-254. doi: 10.1016/j.bbi.2017.11.016. Epub 2017 Nov 22.

CD8+ T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity.

Author information

1
Université Côte d'Azur, CNRS, IPMC, France.
2
Université Côte d'Azur, INSERM, CNRS, IPMC, France.
3
Université Côte d'Azur, C3M, INSERM U 1065, France.
4
Université Côte d'Azur, INSERM, CNRS, IPMC, France. Electronic address: joelle.chabry@ipmc.cnrs.fr.
5
Université Côte d'Azur, CNRS, IPMC, France. Electronic address: alice.guyon@ipmc.cnrs.fr.

Abstract

Enriched environment (EE) induces plasticity changes in the brain. Recently, CD4+ T cells have been shown to be involved in brain plasticity processes. Here, we show that CD8+ T cells are required for EE-induced brain plasticity in mice, as revealed by measurements of hippocampal volume, neurogenesis in the DG of the hippocampus, spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. As a consequence, EE-induced behavioral benefits depend, at least in part, on CD8+ T cells. In addition, we show that spleen CD8+ T cells from mice housed in standard environment (SE) and EE have different properties in terms of 1) TNFα release after in vitro CD3/CD28 or PMA/Iono stimulation 2) in vitro proliferation properties 3) CD8+ CD44+ CD62Llow and CD62Lhi T cells repartition 4) transcriptomic signature as revealed by RNA sequencing. CD8+ T cells purified from the choroid plexus of SE and EE mice also exhibit different transcriptomic profiles as highlighted by single-cell mRNA sequencing. We show that CD8+ T cells are essential mediators of beneficial EE effects on brain plasticity and cognition. Additionally, we propose that EE differentially primes CD8+ T cells leading to behavioral improvement.

KEYWORDS:

Behavior; Brain plasticity; CD8(+) T cells; Choroid plexus; Enriched environment; Hippocampus; Long term potentiation; Mice; Neurogenesis; Synaptogenesis

PMID:
29175168
DOI:
10.1016/j.bbi.2017.11.016

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center