Format

Send to

Choose Destination
Trends Parasitol. 2018 Jan;34(1):6-9. doi: 10.1016/j.pt.2017.11.005. Epub 2017 Nov 23.

Spotlight on CRISPR in Strongyloides Parasitic Nematodes.

Author information

1
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. Electronic address: jward2@ucsc.edu.

Abstract

Parasitic nematodes are biomedically and economically important, but many are genetically intractable which limits our understanding of their molecular and cellular biology. Gang et al. report CRISPR/Cas9 genome editing in parasites of the genus Strongyloides, generating both knock-outs and knock-ins, and demonstrated heritability of the modifications, a crucial advance in the field.

KEYWORDS:

CRISPR; Cas9; Strongyloides; parasitic nematode

PMID:
29174224
PMCID:
PMC5748261
DOI:
10.1016/j.pt.2017.11.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center