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Am J Surg. 2018 Mar;215(3):522-525. doi: 10.1016/j.amjsurg.2017.11.014. Epub 2017 Nov 13.

Cancer history: A predictor of IPMN subtype and dysplastic status?

Author information

1
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
2
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: maxschmi@iupui.edu.

Abstract

INTRODUCTION:

The aim of this study was to determine the association of PMH and FH of pancreatic (PDAC) and non-pancreatic cancers with IPMN malignant risk.

METHODS:

A retrospective review of a prospective database of IPMN patients undergoing resection was performed to assess FH and PMH.

RESULTS:

FH of PDAC was present in 13% of 362 included patients. Of these, 8% had at least one first degree relative (FDR) with PDAC. The rate of PDAC positive FH in non-invasive versus invasive IPMN patients was 14% and 8%, respectively (p = 0.3). In main duct IPMN patients, FH (44%) and PMH of non-pancreatic cancer (16%) was higher than that seen in branch duct IPMN (FH 29%; PMH 6%; p = 0.004 and 0.008).

CONCLUSIONS:

FH of PDAC is not associated with IPMN malignant progression. FH and PMH of non-pancreatic cancer is associated with main duct IPMN, the subtype with the highest rate of invasive transformation.

KEYWORDS:

Family history; IPMN; Malignant progression; Pancreatic ductal adenocarcinoma; Past medical history

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