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Trends Cell Biol. 2018 Feb;28(2):143-156. doi: 10.1016/j.tcb.2017.10.002. Epub 2017 Nov 21.

Zebrafish Infection: From Pathogenesis to Cell Biology.

Author information

1
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.
2
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK. Electronic address: s.mostowy@imperial.ac.uk.

Abstract

The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host-pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans.

KEYWORDS:

autophagy; bacterial infection; cellular microbiology; inflammation; innate immunity; zebrafish

PMID:
29173800
PMCID:
PMC5777827
DOI:
10.1016/j.tcb.2017.10.002
[Indexed for MEDLINE]
Free PMC Article

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