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Semin Radiat Oncol. 2018 Jan;28(1):2-11. doi: 10.1016/j.semradonc.2017.08.005.

Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer.

Author information

1
Wake Forest School of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC.
2
Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA.
3
Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA. Electronic address: jennifer.grandis@ucsf.edu.

Abstract

Large-scale sequencing studies of head and neck squamous cell carcinoma (HNSCC) have elucidated the genetic changes that characterize HNSCC. These findings have supported the development of therapeutic strategies that target key components of aberrant signaling pathways and immune dysregulation. Cumulative evidence suggests that these agents in combination with radiotherapy may have synergistic effects. This review highlights the predictive biomarkers that have been identified from HNSCC genomic studies and implications on the development of molecular-targeting agents that may effectively treat patients with HNSCC, especially when used in combination with radiation.

PMID:
29173752
PMCID:
PMC6293987
DOI:
10.1016/j.semradonc.2017.08.005
[Indexed for MEDLINE]
Free PMC Article

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