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J Pediatr. 2017 Dec;191:96-102. doi: 10.1016/j.jpeds.2017.08.061.

Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents.

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Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain.
School of Sports Organization, Autonomous University of Nuevo Leon, Monterrey, Mexico.
School of Sports Organization, Autonomous University of Nuevo Leon, Monterrey, Mexico. Electronic address:
School of Biological Sciences, Autonomous University of Nuevo Leon, Monterrey, Mexico.
Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Sevilla, Spain.
Research Group Human Movement, University of Lleida, LLeida, Spain.
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.



To compare the responses of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal probrain natriuretic peptide (NT-proBNP) after 60 minutes of swimming in male and female adults and adolescents with different pubertal status.


Adolescent swimmers (25 male and 25 female) and adult swimmers (7 male and 9 female) participated in a 60-minute maximal swimming test with serial assessment of hs-cTnT and NT-proBNP at rest, immediately postexercise, and at 1, 3, 6, 12, and 24 hours postexercise. Adolescents were classified according to pubertal status: Tanner stages 3 (n = 14), 4 (n = 22), and 5 (n = 14).


Exercise resulted in an increase in both biomarkers. hs-cTnT responses to exercise were similar in adolescents with different pubertal status and adults, although there was substantial individual variability in peak hs-cTnT, with the upper reference limit exceeding in 62% of the participants. Postexercise kinetics for hs-cTnT were largely consistent across all groups with a return to near baseline levels 24 hours postexercise. The male participants showed higher values of hs-cTnT at baseline and postexercise. All groups had similar NT-proBNP responses to acute exercise and recovery. One swimmer exceeded the upper reference limit for NT-proBNP.


An exercise-associated increase in hs-cTnT and NT-proBNP occurred in response to a 60-minute maximal swimming test that was independent of pubertal status/adolescent vs adults. The present data also suggests that baseline and postexercise hs-cTnT values are higher in male compared with female, with no sex differences in NT-proBNP values.


NH2-terminal pro-brain natriuretic peptide; Tanner stage; high-sensitivity cardiac troponin T; sex; swimming

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