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Small. 2018 Jan;14(4). doi: 10.1002/smll.201702815. Epub 2017 Nov 24.

Black Phosphorus Quantum Dots with Renal Clearance Property for Efficient Photodynamic Therapy.

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MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, P. R. China.
College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, P. R. China.
Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350001, P. R. China.


Black phosphorus (BP) nanomaterials have emerged as rapidly rising stars in the field of nanomedicine. In this work, BP quantum dots (BPQDs) are synthesized and their potential as photosensitizers is investigated for the first time. The BPQDs present good stability in physiological medium and no appreciable cytotoxicity. More importantly, the BPQDs can be rapidly eliminated from the body in their intact form via renal clearance due to their ultrasmall hydrodynamic diameter (5.4 nm). Both in vitro and in vivo studies indicate that the BPQDs have excellent photodynamic effect under light irradiation that can effectively generate reactive oxygen species to kill cancer cells. The BPQDs thus can serve as biocompatible and powerful photosensitizers for efficient photodynamic therapy.


black phosphorus; photodynamic therapy; photosensitizers; quantum dots; renal clearance


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