A new amino amidine derivative from the wood-decaying fungus Xylaria cf. cubensis SWUF08-86

Nat Prod Res. 2018 Oct;32(19):2260-2267. doi: 10.1080/14786419.2017.1405414. Epub 2017 Nov 24.

Abstract

The secondary metabolites of Xylaria cf. cubensis SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (1), together with five known simple cyclic dipeptide analogs, diketopiperazines (2-6) and eleven other known compounds, including one hemi-cycline (10), three aromatic derivatives (11-13), one sesquiterpene (14) and three sterols (15-17). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, Xylaria cf. cubensis SWUF08-86 has proven to be a diverse secondary metabolites producer.

Keywords: Xylaria cf. cubensis; Xylariaceae; amino amidine; cyclic dipeptide; secondary metabolites.

MeSH terms

  • Amidines / chemistry
  • Amidines / isolation & purification*
  • Anti-Bacterial Agents / isolation & purification
  • Antifungal Agents / isolation & purification
  • Antineoplastic Agents / isolation & purification
  • Dipeptides / chemistry
  • Dipeptides / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Xylariales / chemistry*
  • Xylariales / metabolism

Substances

  • Amidines
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antineoplastic Agents
  • Dipeptides