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Dig Liver Dis. 2018 Jan;50(1):1-5. doi: 10.1016/j.dld.2017.10.025. Epub 2017 Nov 10.

Pancreatic enzyme replacement therapy after gastric resection: An update.

Author information

1
Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy. Electronic address: filippo.antonini@sanita.marche.it.
2
Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Vita e Salute University, Milan, Italy.
3
Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy.
4
Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Abstract

Exocrine pancreatic insufficiency (EPI) is one of the possible mechanisms of fat maldigestion following gastric surgery, together with reduced food intake, loss of gastric reservoir, small bowel bacterial overgrowth and rapid small bowel transit. Oral pancreatic enzyme replacement therapy (PERT) is the mainstay of treatment for EPI. The efficacy and safety of pancreatic enzyme substitution in patients following gastric resection remains unclear. This review article summarizes relevant studies addressing PERT after gastric resection.

KEYWORDS:

Exocrine pancreatic insufficiency; Gastrectomy; Pancreatic enzyme; Surgery

PMID:
29170072
DOI:
10.1016/j.dld.2017.10.025
[Indexed for MEDLINE]

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