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Arch Neurol. 1989 Feb;46(2):138-40.

Aging and Alzheimer's disease. Altered cortical serotonergic binding.

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Sanders-Brown Research Center on Aging, Department of Neurology, University of Kentucky Medical Center, Lexington 40536-0230.


The binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with Alzheimer's disease (AD). Using the dopamine-specific receptor antagonist sulpiride, spiperone binding in the cortex was shown to be essentially serotonergic. A decline in both serotonin and spiperone binding was found in normal aging, and an AD-related decrease was found for spiperone binding only. The AD-related decrement of spiperone binding occurred irrespective of patient age and duration of disease. Scatchard analysis indicates that both age- and disease-related decrements represent a decrease in receptor number.

[Indexed for MEDLINE]

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