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BMC Surg. 2017 Nov 23;17(1):108. doi: 10.1186/s12893-017-0304-0.

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country- Lithuania.

Author information

1
Department of Abdominal Surgery and Oncology, National Cancer Institute, Santariskiu str. 1, Vilnius, 08660, Lithuania.
2
Faculty of Medicine, Vilnius University, Ciurlionio str. 21, Vilnius, 03101, Lithuania.
3
Department of Abdominal Surgery and Oncology, National Cancer Institute, Santariskiu str. 1, Vilnius, 08660, Lithuania. abpelikanas@gmail.com.
4
Faculty of Medicine, Vilnius University, Ciurlionio str. 21, Vilnius, 03101, Lithuania. abpelikanas@gmail.com.
5
School of Medicine, Georgetown University, Washington, D.C., USA.
6
Center of Abdominal surgery, Vilnius University Hospital Santaros Klinikos , Santariskiu str. 2, Washington, 08661, USA.

Abstract

BACKGROUND:

Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania.

METHODS:

A total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed.

RESULTS:

Lymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results.

CONCLUSION:

Our study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.

KEYWORDS:

Early gastric cancer; Lymph node metastasis; Mucosal tumor; Risk factors; T1a

PMID:
29169358
PMCID:
PMC5701498
DOI:
10.1186/s12893-017-0304-0
[Indexed for MEDLINE]
Free PMC Article

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