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Exp Clin Endocrinol Diabetes. 2018 Jun;126(6):342-348. doi: 10.1055/s-0043-122224. Epub 2017 Nov 23.

Sex-Dependent Effect of Metformin on Serum Prolactin Levels In Hyperprolactinemic Patients With Type 2 Diabetes: A Pilot Study.

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1
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
#
Contributed equally

Abstract

BACKGROUND:

Metformin was found to reduce circulating levels of pituitary hormones.

OBJECTIVE:

The purpose of this study was to assess whether sex determines the effect of metformin on lactotroph secretory function.

METHODS:

The study population included 25 women and 12 men with mildly elevated serum prolactin levels (25-75 ng/mL). Because of concomitant type 2 diabetes, all participants were treated with metformin (3 g daily). Plasma levels of glucose and lipids, HOMA1-IR, serum levels of prolactin, thyrotropin and free thyroid hormones, as well as Jostel's, SPINA-GT and SPINA-GD indices were assessed at baseline and at the end of metformin treatment.

RESULTS:

The study completed 24 women and 11 men. At baseline, there were no significant differences in circulating levels of glucose and lipids, insulin sensitivity, hormones, Jostel's, SPINA-GT and SPINA-GD indices between women and men. In both men and women, metformin reduced fasting glucose levels and HOMA1-IR. However, only in women metformin decreased elevated prolactin levels and this effect correlated with an improvement insulin sensitivity, as well as with the impact on SPINA-GT.

CONCLUSIONS:

The results of the study suggest that the effect of metformin on serum prolactin levels is sex-dependent.

PMID:
29169197
DOI:
10.1055/s-0043-122224
[Indexed for MEDLINE]

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