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Cell Adh Migr. 2017 Dec 29:1-9. doi: 10.1080/19336918.2017.1405208. [Epub ahead of print]

The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.

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1
a The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney , Sydney, NSW , Australia.

Abstract

The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer.

KEYWORDS:

Cancer; Extracellular Matrix; Kinase Signalling; Lysyl Oxidase; Metastasis; Remodelling

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