Format

Send to

Choose Destination
Transfusion. 2018 Jan;58(1):16-24. doi: 10.1111/trf.14401. Epub 2017 Nov 22.

Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study.

Author information

1
Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.
2
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
3
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
4
Haga Hospital, Den Haag, the Netherlands.
5
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
6
Hematology Center, Karolinska University Hospital, Stockholm, Sweden.
7
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
8
Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
9
Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
10
Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
11
Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
12
Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark.

Abstract

BACKGROUND:

Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion.

STUDY DESIGN AND METHODS:

We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days.

RESULTS:

A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95% confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95% CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture.

CONCLUSION:

Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.

PMID:
29168187
DOI:
10.1111/trf.14401
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center