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Clin Sci (Lond). 2018 Jan 25;132(2):295-312. doi: 10.1042/CS20171416. Print 2018 Jan 31.

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development.

Author information

1
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
2
Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
3
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
4
Department of Nephrology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
5
Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
6
Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
7
Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
8
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
9
Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10
Department of Pharmacology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A. bgrayson@umc.edu.
11
Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
12
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A. bgrayson@umc.edu.

Abstract

Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism, and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3+ and CD8+) populations compared with lean or obese controls. Further, local interleukin (IL) and IL 1 receptor antagonist (il1rn) cmRNA were increased in placenta of VSG dams. Placental barrier function was also affected, with increased transplacental permeability to small molecules, increased matrix metalloproteinase 9 expression, and increased apoptosis in VSG. Furthermore, we identified increased placental mTOR signaling that may contribute to preserving the body weight of the fetuses during gestation. These changes occurred in the absence of a macronutrient deficit or gestational hypertension in the VSG dams. In summary, previous VSG in dams may contribute to fetal demise by affecting maternal immune system activity and compromise placental integrity.

KEYWORDS:

bariatric surgery; immunomodulation; inflammation; obesity; placenta; pregnancy

PMID:
29167317
PMCID:
PMC5989318
DOI:
10.1042/CS20171416
[Indexed for MEDLINE]
Free PMC Article

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