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Nutrients. 2017 Nov 22;9(11). pii: E1270. doi: 10.3390/nu9111270.

Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study.

Author information

1
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. kyle.raubenheimer@connect.qut.edu.au.
2
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. kyle.raubenheimer@connect.qut.edu.au.
3
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. danica.hickey@qut.edu.au.
4
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, OLD 4059, Australia. michael.leveritt@uq.edu.au.
5
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, OLD 4059, Australia. r.fassett@uq.edu.au.
6
Institute of Sport Exercise and Active Living, Victoria University, Melbourne, VIC 8001, Australia. joaquin.ortizdezevallosmunoz@live.vu.edu.au.
7
Institute of Sport Exercise and Active Living, Victoria University, Melbourne, VIC 8001, Australia. Jason.Allen@vu.edu.au.
8
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, OLD 4059, Australia. d.briskey@uq.edu.au.
9
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. a.parker@qut.edu.au.
10
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. a.parker@qut.edu.au.
11
School of Exercise and Nutrition Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. g.kerr@qut.edu.au.
12
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. jonathan.peake@qut.edu.au.
13
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. jonathan.peake@qut.edu.au.
14
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. n.pecheniuk@qut.edu.au.
15
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. oliver.neubauer@qut.edu.au.
16
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia. oliver.neubauer@qut.edu.au.

Abstract

Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0.04 mmol nitrate) on blood pressure, blood coagulation, vascular inflammation markers, plasma nitrate and nitrite before, and 3 h and 6 h after ingestion in healthy older adults (five males, seven females, mean age: 64 years, age range: 57-71 years) in a randomized, placebo-controlled, crossover study. Plasma nitrate and nitrite increased 3 and 6 h after HI-NI ingestion (p < 0.05). Systolic, diastolic and mean arterial blood pressure decreased 3 h relative to baseline after HI-NI ingestion only (p < 0.05). The number of blood monocyte-platelet aggregates decreased 3 h after HI-NI intake (p < 0.05), indicating reduced platelet activation. The number of blood CD11b-expressing granulocytes decreased 3 h following HI-NI beetroot juice intake (p < 0.05), suggesting a shift toward an anti-adhesive granulocyte phenotype. Numbers of blood CD14++CD16⁺ intermediate monocyte subtypes slightly increased 6 h after HI-NI beetroot juice ingestion (p < 0.05), but the clinical implications of this response are currently unclear. These findings provide new evidence for the acute effects of nitrate-rich beetroot juice on circulating immune cells and platelets. Further long-term research is warranted to determine if these effects reduce the risk of developing hypertension and vascular inflammation with aging.

KEYWORDS:

aging; anti-adhesive effects; anti-thrombotic effects; beetroot juice; blood pressure; dietary nitrate; low-grade inflammation; preserving vascular health; thrombosis

PMID:
29165355
PMCID:
PMC5707742
DOI:
10.3390/nu9111270
[Indexed for MEDLINE]
Free PMC Article

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