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Curr Med Chem. 2017 Nov 20. doi: 10.2174/0929867324666171121102829. [Epub ahead of print]

High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors Against Staphylococcus Aureus.

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1
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055. China.

Abstract

The increasing threats of antibiotic resistance urge the need for developing new approaches to combat bacterial infections. Unlike conventional antibiotics that aim to kill bacteria or inhibit their growth, targeting bacterial virulence may be a promising alternative approach, which imposes weaker selective pressure for the generation of resistance. Here, we review the pathways related to staphylococcal virulence, summarize the high-throughput screening strategies used to identify novel anti-virulence inhibitors, and discuss the advantages and disadvantages of these strategies.

KEYWORDS:

ClpP; High-throughput screen; SarA/MgrA; Staphylococcus aureus; Stp1.; agr; anti-virulence; sortase

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