Send to

Choose Destination
Front Cell Dev Biol. 2017 Nov 7;5:95. doi: 10.3389/fcell.2017.00095. eCollection 2017.

Interorganelle Communication between Mitochondria and the Endolysosomal System.

Author information

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.


The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.


aging; autophagy; exosomes; lysosome; proteostasis; quality control

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center