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Front Immunol. 2017 Oct 30;8:1422. doi: 10.3389/fimmu.2017.01422. eCollection 2017.

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System.

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Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany.


Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell-cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.


Th2 cells; allergic inflammation; alternatively activated macrophages; basophils; eosinophils; helminths; innate lymphoid cells; mast cells

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