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Sci Rep. 2017 Nov 21;7(1):15906. doi: 10.1038/s41598-017-16173-z.

Ultrasonographic measurement of the optic nerve sheath diameter and its association with eyeball transverse diameter in 585 healthy volunteers.

Author information

1
Department of Radiology, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do, 363-849, Republic of Korea.
2
Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul, Korea.
3
Department of Neurology, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do, 363-849, Republic of Korea. arkrk86@gmail.com.

Abstract

The optic nerve sheath diameter (ONSD) is considered as an indirect marker for intracranial pressure (ICP). However, the optimal cut-off value for an abnormal ONSD indicating elevated ICP and its associated factors have been unclear. Thus, we investigated normative values for the ONSD using ultrasonography and investigate the potential factors affecting it. We prospectively recruited healthy volunteers between September 2016 and March 2017. A total of 585 individuals were included, in which the mean ONSD was 4.11 mm [95% confidence interval (CI), 4.09-4.14 mm]. Although ONSD was correlated with sex (p = 0.015), height (p = 0.003), and eyeball transverse diameter (ETD) (p < 0.001) in simple linear regression analyses, multiple linear regression analysis revealed that only ETD was independently associated with ONSD (p < 0.001). Accordingly, we further established a normative value for the ONSD/ETD ratio and its associated factors. The mean ONSD/ETD ratio was 0.18 (95% CI, 0.18-0.18), but the ONSD/ETD ratio was not correlated with sex, height, weight, body mass index, and head circumference. Our findings suggest that the ONSD had a strong correlation with ETD, and ONSD/ETD ratio might provide more reliable data than ONSD itself as a marker of ICP.

PMID:
29162911
PMCID:
PMC5698472
DOI:
10.1038/s41598-017-16173-z
[Indexed for MEDLINE]
Free PMC Article

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