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Neurosci Biobehav Rev. 2018 Jan;84:162-170. doi: 10.1016/j.neubiorev.2017.11.005. Epub 2017 Nov 21.

Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data.

Author information

1
Department of Neuroscience, Medical School, University of Sheffield, Sheffield, UK; Department of Psychosis Studies, Institute of Psychiatry Psychology & Neuroscience, King's College London, UK.
2
Translational MRI, Department of Imaging & Pathology, KU Leuven, Belgium; Department of Old Age Psychiatry, University Psychiatry Centre (UPC), KU Leuven, Belgium; Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
3
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
4
Department of Psychology, City, University of London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, UK.
5
Department of Psychiatry, University of Geneva, Switzerland.
6
National Brain Mapping Centre, Shahid Beheshti University, General and Medical Campus, Tehran, Iran.
7
Department of Psychosis Studies, Institute of Psychiatry Psychology & Neuroscience, King's College London, UK.
8
Centre for Affective Disorders, Institute of Psychiatry Psychology & Neuroscience, King's College London, UK.
9
Department of Psychiatry, University of Oxford, Oxford, UK.
10
Affidea CDRC - Centre Diagnostique Radiologique de Carouge, Switzerland; Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden; Department of Neuroradiology, University Hospital Freiburg, Germany; Faculty of Medicine of the University of Geneva, Switzerland.
11
Icahn School of Medicine at Mount Sinai, New York, USA.
12
Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
13
Department of Psychosis Studies, Institute of Psychiatry Psychology & Neuroscience, King's College London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, UK. Electronic address: matthew.kempton@kcl.ac.uk.

Abstract

Converging evidence suggests that bipolar disorder (BD) is associated with white matter (WM) abnormalities. Meta-analyses of voxel based morphometry (VBM) data is commonly performed using published coordinates, however this method is limited since it ignores non-significant data. Obtaining statistical maps from studies (T-maps) as well as raw MRI datasets increases accuracy and allows for a comprehensive analysis of clinical variables. We obtained coordinate data (7-studies), T-Maps (12-studies, including unpublished data) and raw MRI datasets (5-studies) and analysed the 24 studies using Seed-based d Mapping (SDM). A VBM analysis was conducted to verify the results in an independent sample. The meta-analysis revealed decreased WM volume in the posterior corpus callosum extending to WM in the posterior cingulate cortex. This region was significantly reduced in volume in BD patients in the independent dataset (p=0.003) but there was no association with clinical variables. We identified a robust WM volume abnormality in BD patients that may represent a trait marker of the disease and used a novel methodology to validate the findings.

KEYWORDS:

Bipolar disorder; MRI; Meta-analysis; VBM; White matter

PMID:
29162519
PMCID:
PMC5771263
DOI:
10.1016/j.neubiorev.2017.11.005
[Indexed for MEDLINE]
Free PMC Article

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