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Trends Mol Med. 2017 Dec;23(12):1103-1120. doi: 10.1016/j.molmed.2017.10.006. Epub 2017 Nov 20.

Nerve Stimulation: Immunomodulation and Control of Inflammation.

Author information

1
Center for Immunology and Inflammation, Department of Surgery, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA; International Laboratory of Neuro-Immunomodulation, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China. Electronic address: luis.ulloa@rutgers.edu.
2
Center for Immunology and Inflammation, Department of Surgery, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA.
3
Center for Immunology and Inflammation, Department of Surgery, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA; Universidad Autónoma 'Benito Juárez' de Oaxaca, 68120 Mexico.

Abstract

Neuronal stimulation is an emerging field in modern medicine to control organ function and re-establish physiological homeostasis during illness. Transdermal nerve stimulation with electroacupuncture is currently endorsed by the World Health Organization (WHO) and the National Institutes of Health (NIH), and is used by millions of people to control pain and inflammation. Recent advances in electroacupuncture may permit activation of specific neuronal networks to prevent organ damage in inflammatory and infectious disorders. Experimental studies of nerve stimulation are also providing new information on the functional organization of the nervous system to control inflammation and its clinical implications in infectious and inflammatory disorders. These studies may allow the design of novel non-invasive techniques for nerve stimulation to help to control immune and organ functions.

KEYWORDS:

infectious diseases; inflammation; nerve stimulation; neuromodulation

PMID:
29162418
PMCID:
PMC5724790
DOI:
10.1016/j.molmed.2017.10.006
[Indexed for MEDLINE]
Free PMC Article

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