Send to

Choose Destination
Neuropsychol Rehabil. 2019 Sep;29(8):1273-1289. doi: 10.1080/09602011.2017.1391103. Epub 2017 Nov 21.

Cognitive rehabilitation for individuals with opioid use disorder: A randomized controlled trial.

Author information

a Department of Cognitive Psychology , Institute for Cognitive Science Studies , Tehran , Iran.
b Department of Psychology, Faculty of Psychology and Education , University of Tehran , Tehran , Iran.
c Substance Abuse and Dependence Research Center , University of Social Welfare and Rehabilitation Sciences , Tehran , Iran.
d Department of Psychiatry, School of Medicine , Yale University , CT , USA.
e VA Connecticut Healthcare System , West Haven , CT , USA.
f Neurocognitive Laboratory, Iranian National Center for Addiction Studies (INCAS) , Tehran University of Medical Sciences (TUMS) , Tehran , Iran.
g Neuroscience and Addiction Studies Department, School of Advanced Technologies in Medicine (SATiM) , Tehran University of Medical Sciences (TUMS) , Tehran , Iran.
h Clinical Department, School of Medicine , Arak University of Medical Sciences , Arak , Iran.
i Translational Neuroscience Program , Institute for Cognitive Science Studies , Tehran , Iran.
j Research Center for Molecular and Cellular Imaging , Tehran University of Medical Sciences , Tehran , Iran.


Aim: To examine the efficacy of cognitive rehabilitation treatment (CRT) for people with opioid use disorder who were recruited into a methadone maintenance treatment (MMT) programme. Method: 120 male subjects were randomly assigned to (1) MMT plus CRT in two months or (2) MMT plus a control intervention. Subjects were assessed at the beginning, mid-point and post-intervention as well as at 1-, 3- and 6-month follow-up time points. Results: Analysis with repeated measure ANOVA showed that the CRT group performed significantly better in tests of learning, switching, processing speed, working memory and memory span. Moreover, the CRT group had significantly lower opiate use over the control group during 3-months follow-up. Analysis including only those with a history of methamphetamine use showed that the CRT group had significantly lower amphetamine use. No group differences were observed for treatment retention. Conclusions: Our findings provide evidence that adding CRT as an adjunct intervention to MMT can improve cognitive performance as well as abstinence from both opiates and stimulants.


Abstinence; Cognitive rehabilitation; Methadone maintenance treatment; Opioid; Retention

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center