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Blood Purif. 2018;45(1-3):28-35. doi: 10.1159/000480222. Epub 2017 Nov 22.

Maintained Folic Acid Supplementation Reduces the Risk of Mortality in Continuous Ambulatory Peritoneal Dialysis Patients.

Author information

1
Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Abstract

BACKGROUND:

The association between folic acid (FA) supplementation and mortality in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear.

METHODS:

FA exposure was calculated as a percentage of cumulative duration of drug usage to total follow-up duration (FA%). A total of 1,358 patients were classified by a cutoff value of FA%. The association of FA with mortality was evaluated using Cox proportional hazards models.

RESULTS:

The cutoff value of FA% for predicting mortality was <34% at a median follow-up of 40.7 months. FA ≥34% was associated with decreased risk for all-cause (adjusted hazard ratios [HRs] 95% CI 0.64 [0.48-0.85] and cardiovascular mortality 0.67 (95% CI 0.47-0.97). Moreover, the adjusted HRs per 10% higher FA for all-cause and cardiovascular mortality were 0.925 (95% CI 0.879-0.973) and 0.926 (95% CI 0.869-0.988), respectively.

CONCLUSIONS:

Longer period of FA supplementation led to a reduction in risk of both all-cause and cardiovascular mortality in CAPD patients.

KEYWORDS:

All-cause mortality; Cardiovascular mortality; Folic acid; Peritoneal dialysis

PMID:
29161705
DOI:
10.1159/000480222
[Indexed for MEDLINE]

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