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Alzheimers Dement (Amst). 2017 Sep 5;10:12-21. doi: 10.1016/j.dadm.2017.08.001. eCollection 2018.

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly.

Author information

1
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
2
Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
3
Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
4
Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao Medical University, Shandong, PR China.
5
Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

Abstract

Introduction:

The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear.

Methods:

We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models.

Results:

A total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [18F]fluorodeoxyglucose standardized uptake value ratio but higher amyloid burden represented by higher [18F]florbetapir standardized uptake value ratio and lower cerebrospinal fluid amyloid β 1-42 levels compared to those without ventriculomegaly.

Discussion:

Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and/or normal pressure hydrocephalus.

KEYWORDS:

Alzheimer's disease; Biomarker; Idiopathic normal pressure hydrocephalus; Neuropsychological test; Ventriculomegaly

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