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Signal Transduct Target Ther. 2017;2. pii: 17023. doi: 10.1038/sigtrans.2017.23. Epub 2017 Jul 14.

NF-κB signaling in inflammation.

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Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA.


The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.

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