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Hematol Oncol Clin North Am. 2018 Feb;32(1):119-139. doi: 10.1016/j.hoc.2017.09.010.

POEMS Syndrome: Diagnosis and Investigative Work-up.

Author information

1
Division of Hematology, Department of Medicine, Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: Dispenzieri.angela@mayo.edu.
2
Division of Hematology, Department of Medicine, Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Abstract

POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. This rare disorder should not be missed, especially if the patient has a putative diagnosis of chronic inflammatory polyradiculoneuropathy, a lambda restricted monoclonal gammopathy, and thrombocytosis, and is not responding as expected to immunomodulatory therapy commonly used for chronic inflammatory polyradiculoneuropathy.

KEYWORDS:

Castleman disease; Chronic inflammatory polyradiculoneuropathy; Paraneoplastic; Plasma cell disorder

PMID:
29157614
DOI:
10.1016/j.hoc.2017.09.010
[Indexed for MEDLINE]

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