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Stem Cell Res. 2017 Dec;25:213-216. doi: 10.1016/j.scr.2017.10.025. Epub 2017 Nov 3.

Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation.

Author information

1
Department of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
2
School of life sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
3
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA; Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai 200120, China.
4
Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, and The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China.
5
School of life sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: zhangst@zzu.edu.cn.
6
Department of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: xuyuming@zzu.edu.cn.

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Previous studies have identified mutations in several genes, such as amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2), in patients with early-onset (<65years) familial AD. Recently, a patient with an APP gene mutation was identified; the dermal fibroblasts of the patient were obtained and a line of induced pluripotent stem cells (iPSCs) was successfully generated using the Sendai-virus (SeV) delivery system. The iPSC line will be useful for further study of the pathomechanism and drug screening for AD.

PMID:
29156377
DOI:
10.1016/j.scr.2017.10.025
[Indexed for MEDLINE]
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