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Environ Res. 2018 Feb;161:122-128. doi: 10.1016/j.envres.2017.11.002. Epub 2017 Nov 20.

Urinary bisphenol A concentrations are associated with reproductive parameters in young men.

Author information

1
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, 30100 Murcia, Spain.
2
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, 30100 Murcia, Spain; Health Research Methodology Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain. Electronic address: jaime.mendiola@um.es.
3
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain.
4
Department of Growth and Reproduction, and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.
5
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 10029 New York, NY, USA.
6
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, 30100 Murcia, Spain; Health Research Methodology Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Preventive Medicine, "Virgen de la Arrixaca" University Clinical Hospital, El Palmar, 30120 Murcia, Spain.

Abstract

Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. Several observational studies have investigated the associations between BPA exposure and male reproductive function, but findings are inconsistent. The objective of this study was to assess the associations between urinary BPA concentrations and semen quality and reproductive hormone levels in a cross-sectional study with 215 healthy young university students (18-23 years old), investigated between 2010 and 2011 in Southern Spain (Murcia Region). All subjects provided urine, blood serum and semen samples on a single day. Urinary BPA concentrations were measured by dispersive liquid-liquid microextraction and ultra-high performance liquid chromatography with tandem mass spectrometry detection. Semen quality was evaluated by measuring volume, concentration, motility, morphology and total sperm count (TSC). Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, inhibin B and estradiol. Relationships between urinary BPA concentrations and semen quality parameters and reproductive hormone levels were examined using linear regression, adjusting for potential confounders and covariates. Ninety-five percent of the men had detectable urinary BPA concentrations with unadjusted median (5th-95th) of 2.8 (0.16-11.5) ng/mL. After adjustment for important covariates, there was a significant positive association between urinary BPA concentrations and serum LH levels (β = 0.07, 95%CI: 0.02;0.12, p-value < 0.01). Urinary BPA concentration was also significantly and inversely associated with sperm concentration (β = - 0.04, 95%CI: - 0.07;- 0.02, p-value < 0.01) and TSC (β = - 0.05, 95%CI: - 0.08;- 0.02, p-value < 0.01). No significant associations were found between BPA and other semen parameters or reproductive hormone levels. Our results support the hypothesis that BPA exposure may be associated with a reduction in Leydig cell capacity (increased LH levels) and decreased sperm counts in young men.

KEYWORDS:

Bisphenol A; Endocrine disruptors; Reproductive hormones; Semen quality

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