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PLoS One. 2017 Nov 20;12(11):e0188423. doi: 10.1371/journal.pone.0188423. eCollection 2017.

Longitudinal fasting blood glucose patterns and arterial stiffness risk in a population without diabetes.

Author information

1
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
2
Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
3
Graduate School, North China University of Science and Technology, Tangshan, China.
4
School of Public Health, North China University of Science and Technology, Tangshan, China.
5
Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Abstract

OBJECTIVE:

To identify long-term fasting blood glucose trajectories and to assess the association between the trajectories and the risk of arterial stiffness in individuals without diabetes.

METHODS:

We enrolled 16,454 non-diabetic participants from Kailuan cohort. Fasting blood glucose concentrations were measured in 2006, 2008, and 2010 survey. Brachial-ankle pulse wave velocities were measured during 2011 to 2016. Multivariate regression model was used to estimate the difference of brachial-ankle pulse wave velocity levels and logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs) of arterial stiffness risk, according to the fasting blood glucose trajectories.

RESULTS:

We identified five distinct fasting blood glucose trajectories and each of the trajectories was labeled according to its range and change over 2006-2010 survey: elevated-stable pattern (5.0% of participants), elevated-decreasing pattern (6.6%), moderate-increasing pattern (10.9%), moderate-stable pattern (59.3%), and low-stable pattern (18.2%). After adjustment for potential confounders, individuals with elevated-stable pattern had a 42.6 cm/s (95%CI: 24.7 to 60.6 cm/s) higher brachial-ankle pulse wave velocity level and a 37% (OR 1.37, 95%CI: 1.14 to 1.66) higher arterial stiffness risk, and individuals with moderate-increasing pattern had a 19.6 cm/s (95%CI: 6.9 to 32.3 cm/s) higher brachial-ankle pulse wave velocity level and a 17% (OR 1.17, 95%CI: 1.03 to 1.33) higher arterial stiffness risk, related to individuals with moderate-stable pattern. We did not find significant associations of the elevated-decreasing or low-stable patterns with arterial stiffness. Consistently, the cumulative average, variability, and increased rate of fasting blood glucose during 2006-2010 survey were significantly associated with the arterial stiffness risk.

CONCLUSION:

Discrete fasting blood glucose trajectories were associated with the arterial stiffness risk in non-diabetic individuals.

PMID:
29155890
PMCID:
PMC5695806
DOI:
10.1371/journal.pone.0188423
[Indexed for MEDLINE]
Free PMC Article

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