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ESC Heart Fail. 2017 Nov;4(4):409-416. doi: 10.1002/ehf2.12158. Epub 2017 Apr 10.

Relationship between skeletal muscle mass and cardiac function during exercise in community-dwelling older adults.

Author information

1
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
2
Department of Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
3
Tokyo University of Technology, Tokyo, Japan.
4
Ochanomizu University, Tokyo, Japan.
5
Health Management Services Inc., Tokyo, Japan.
6
Department of Rehabilitation, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
7
Department of Cardiology and Pneumology, Institute of Innovative Clinical Trials, University Medical Center Göttingen, Göttingen, Germany.
8
Department of Cardiac Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
9
Department of Diabetes, Metabolism and Endocrinology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.

Abstract

AIMS:

This study aimed to investigate the relationship between skeletal muscle mass and cardiac functional parameters in older adults during cardiopulmonary exercise testing (CPET).

METHODS AND RESULTS:

Sixty-three Japanese community-dwelling older adults were enrolled (20 men and 43 women; mean age 80 years, range 65-97 years). Cardiac functional parameters during exercise were assessed using CPET. Skeletal muscle mass index (SMI) was calculated by dividing the appendicular lean mass (measured using dual-energy X-ray absorptiometry) by height in metres squared. Subjects were divided into two groups: men with SMI ≥ 7.0 kg/m2 and women with SMI ≥ 5.4 kg/m2 (non-sarcopenic group); or men with SMI < 7.0 kg/m2 and women with SMI < 5.4 kg/m2 (sarcopenic group). There were significant positive correlations between SMI and peak oxygen uptake (VO2 ) (r = 0.631, P < 0.001), and between SMI and peak VO2 /heart rate (HR) (r = 0.683, P < 0.001). However, only peak VO2 /HR significantly differed between groups in both sexes. Multiple linear regression analyses with peak VO2 /HR as a dependent variable showed that SMI was the only independent determinant after adjusting for potential confounders. After 4 month follow-up of 47 participants, there was still a significant positive correlation between SMI and peak VO2 /HR (r = 0.567, P < 0.001), and between percent change of SMI and percent change of peak VO2 /HR (r = 0.305, P < 0.05).

CONCLUSIONS:

Peak VO2 /HR, an index of stroke volume at peak exercise, was associated with SMI. This indicates that skeletal muscle mass might affect cardiac function during exercise.

KEYWORDS:

Cardiopulmonary exercise testing; Community-dwelling older adults; Peak oxygen pulse; Sarcopenia; Skeletal muscle mass index

PMID:
29154420
PMCID:
PMC5695195
DOI:
10.1002/ehf2.12158
[Indexed for MEDLINE]
Free PMC Article

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