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Trends Biotechnol. 2018 Feb;36(2):199-215. doi: 10.1016/j.tibtech.2017.10.010. Epub 2017 Nov 15.

Basic and Clinical Approaches for Fertility Preservation and Restoration in Cancer Patients.

Author information

1
Reproductive Medicine Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain. Electronic address: jose_medrano@iislafe.es.
2
Pediatric Oncology Unit, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
3
Reproductive Medicine Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain; Pediatric Oncology Unit, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
4
Reproductive Medicine Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain; Fundación IVI, 46026 Valencia, Spain.
5
Reproductive Medicine Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain.
6
Biology of the Testis, Research Laboratory for Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.

Abstract

As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest. In this review, we discuss the latest updates in fertility preservation from a basic and a clinical point of view.

KEYWORDS:

fertility preservation; germ cell transplantation; in vitro differentiation; in vitro maturation; ovarian cortex cryopreservation; testicular tissue grafting

PMID:
29153762
DOI:
10.1016/j.tibtech.2017.10.010
[Indexed for MEDLINE]

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