Format

Send to

Choose Destination
Curr Opin Cell Biol. 2018 Apr;51:15-21. doi: 10.1016/j.ceb.2017.10.003. Epub 2017 Dec 6.

Mechanical cell competition.

Author information

1
Cell Fitness Laboratory, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.
2
Cell Fitness Laboratory, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal. Electronic address: eduardo.moreno@research.fchampalimaud.org.

Abstract

Maintenance of tissue organization is crucial to ensure normal organ function and organism viability. Tissues are loaded with the ability to sense the available space, measuring cell density and adapting their behaviour accordingly. To keep homeostasis, compression pressure generated by local cell density increment triggers cell elimination. During mechanical cell competition, winner cells compress the neighbouring cells, promoting tissue crowding, which leads to cell elimination. Thus, the hypersensitivity to crowding may confer a loser status, whereas resistance to mechanical-induced elimination may favour a winner status. Here we analyse the emerging field of mechanical cell competition, describing the mechanotransducers implicated in cell elimination. Furthermore, we highlight the dual role of mechanical cell competition (MCC) as tumour suppression or expansion mechanisms.

PMID:
29153702
DOI:
10.1016/j.ceb.2017.10.003
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center