Format

Send to

Choose Destination
Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12905. Epub 2017 Nov 20.

Oestradiol-17β is a local factor inducing the early stage of spermatogenesis in mouse testes.

Author information

1
Department of Animal Science, Agricultural College of Yanbian University, Yanji Jilin, China.
2
Department of Animal Biotechnology, College of Ecology and Environment Science, Kyungpook National University, Sangju, Korea.

Abstract

This study was undertaken to elucidate the effect of testicular oestradiol-17β (E2 ) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E2 . E2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E2 is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.

KEYWORDS:

follicle-stimulating hormone; oestradiol-17β; spermatocytogenesis; testicular germ cells; testosterone

PMID:
29152782
DOI:
10.1111/and.12905
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center