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Cureus. 2017 Sep 10;9(9):e1670. doi: 10.7759/cureus.1670.

Dramatic Response of a Large Sacral Chordoma to Intensity Modulated Proton Beam Therapy.

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Radiation Oncology, University of Maryland School of Medicine.


Sacral chordomas are slow-growing, indolent, and locally invasive tumors that typically present with pain and neurologic dysfunction. Wide en-bloc surgical excision is the primary treatment, but achieving adequate margins is difficult and surgery is often associated with significant morbidity. Adjuvant radiation therapy (RT) is utilized to decrease the risk of local recurrence or as definitive treatment for nonsurgical candidates. Although chordomas are considered to be relatively radioresistant tumors, several studies have demonstrated tumor response to high-dose proton therapy. Here, we present a patient with a large sacral chordoma who underwent definitive treatment with intensity-modulated proton therapy (IMPT).


chordoma; intensity modulated proton therapy (impt); pencil beam scanning proton therapy; sacral chordoma

Conflict of interest statement

The authors have declared that no competing interests exist.

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