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Clin Case Rep. 2017 Sep 27;5(11):1852-1855. doi: 10.1002/ccr3.1193. eCollection 2017 Nov.

Mexican case report of a never-treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke.

Author information

1
Escuela de Medicina Tecnologico de Monterrey Monterrey México.
2
Fundación de Investigación HM Hospitales Madrid Spain.
3
Neurocenter Monterrey Nuevo León México.

Abstract

Glucose and lipid profile together with blood pressure should always be considered for low sera-IGF-1 patients. Even when adulthood is reached, IGF-1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.

KEYWORDS:

GH insensitivity; GH/IGF‐1 axis; GHR; IGF‐1; Laron syndrome; metabolic syndrome; obesity; stroke; type 2 diabetes

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