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Clin Case Rep. 2017 Sep 27;5(11):1852-1855. doi: 10.1002/ccr3.1193. eCollection 2017 Nov.

Mexican case report of a never-treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke.

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Escuela de Medicina Tecnologico de Monterrey Monterrey México.
Fundación de Investigación HM Hospitales Madrid Spain.
Neurocenter Monterrey Nuevo León México.


Glucose and lipid profile together with blood pressure should always be considered for low sera-IGF-1 patients. Even when adulthood is reached, IGF-1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.


GH insensitivity; GH/IGF‐1 axis; GHR; IGF‐1; Laron syndrome; metabolic syndrome; obesity; stroke; type 2 diabetes

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