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J Cell Physiol. 2018 Aug;233(8):5613-5622. doi: 10.1002/jcp.26273. Epub 2018 Mar 1.

Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer.

Author information

1
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, United Kingdom.
7
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Toll like receptor (TLR) signaling is involved in activating innate and adaptive immune responses and plays a critical role in inflammation-induced diseases such as colorectal cancer (CRC). Dysregulation of this signaling pathway can result in disturbance of epithelial layer hemostasis, chronic inflammatory, excessive repair responses, and development of CRC. There is now substantial evidence for the benefit of targeting of this pathway in cancer treatment, and several agents have been approved, such as BCG (Bacillus Calmette Guérin), MPL (monophosphoryl lipid A) and imiquimod. This review summarizes the current knowledge about the different functions of TLRs on tumor cells and their application in cancer therapy with particular emphasis on recent preclinical and clinical research in treatment of CRC.

KEYWORDS:

colorectal cancer; immune responses; inflammation; signaling pathway; toll like receptor

PMID:
29150944
DOI:
10.1002/jcp.26273
[Indexed for MEDLINE]

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