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Brain Dev. 2018 Mar;40(3):211-217. doi: 10.1016/j.braindev.2017.10.006. Epub 2017 Nov 14.

Type I interferon and proinflammatory cytokine levels in cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy.

Author information

1
Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea. Electronic address: pdsnoopy@naver.com.
2
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
3
Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Abstract

OBJECTIVE:

The purpose of this study was to identify whether there is an increase in type I interferon and proinflammatory cytokine levels in the cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy.

METHODS:

Levels of type I interferons (interferon-alpha and interferon-beta) and proinflammatory cytokines (interleukin-6 and interferon-gamma) were measured in the cerebrospinal fluid of 23 newborns with rotavirus-associated leukoencephalopathy (patient group) and 39 infants under 90 days-of-age (control group).

RESULTS:

Cerebrospinal fluid pleocytosis was not observed in either group. Cerebrospinal fluid interleukin-6 levels were significantly higher in the patient group (7.02 ± 5.88 pg/mL) than in the control group (1.14 ± 1.90 pg/mL) (p < .0001). The mean cerebrospinal fluid interferon-gamma levels of the patient group (24.43 ± 40.16 pg/mL) were also significantly higher than those of the controls group (0.0 ± 0.0 pg/mL) (p < .0001). Cerebrospinal fluid interferon-alpha was not detected in any patient (0%) from the patient group, but was detected in four (10.3%) of the controls. Interferon-beta was detected in only two patients (8.7%) from the patient group and in one (2.6%) of the controls. Cerebrospinal fluid interleukin-6 levels correlated positively with the extent of white matter lesions on diffusion-weighted magnetic resonance imaging (r = 0.607, p = .002).

CONCLUSIONS:

Significant increases in proinflammatory cytokine levels accompanied by very low detection rates of type I interferon in cerebrospinal fluid indicate that rotavirus-associated leukoencephalopathy in newborns can be correlated with central nervous system inflammatory processes without direct virus invasion into the central nervous system.

KEYWORDS:

Cerebrospinal fluid; Interferon-gamma; Interleukin-6; Leukoencephalopathy; Newborn; Rotavirus; Type I interferon

PMID:
29150375
DOI:
10.1016/j.braindev.2017.10.006
[Indexed for MEDLINE]

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