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Trends Endocrinol Metab. 2018 Jan;29(1):8-17. doi: 10.1016/j.tem.2017.10.009. Epub 2017 Nov 14.

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.

Author information

1
Institute of Nutrition and Food Technology 'José Mataix Verdú', Department of Physiology, Biomedical Research Center, University of Granada, 18100 Granada, Spain. Electronic address: mdcormor@ugr.es.
2
Rob Steiner Unit, Hammersmith Hospital, London W12 0NN, UK.
3
Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France and IDM, University of Cape Town, Cape Town, South Africa.

Abstract

The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and metabolic risk and has also been implicated in the development of major aging-related diseases such as gout, type 2 diabetes, obesity, cancer, and neurodegenerative and cardiovascular disorders. Several pathways regulating the NLRP3 inflammasome are currently being studied, but how the NLRP3 inflammasome is regulated remains unknown. AMP-activated protein kinase (AMPK), a central regulator of multiple metabolic pathways involved in the pathophysiology of aging and age-related diseases, has emerged as an important integrator of signals controlling inflammation including the inflammasome. In this Opinion article, we show that several AMPK-dependent pathways regulate NLRP3 inflammasome activation during aging, suggesting NLRP3 as a potential pharmacological target in age-related diseases.

KEYWORDS:

AMPK; NLRP3 inflammasome; aging; autophagy

PMID:
29150317
DOI:
10.1016/j.tem.2017.10.009
[Indexed for MEDLINE]

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